Oncogenic mechanisms in renal insufficiency

Renal dopamine system in chronic renal insufficiency

In the periphery, physiological dopamine increases renal blood flow, decreases renal resistance and acts on the kidney tubule to enhance natriuresis and diuresis. Dopamine receptors can be divided into D1-like (D1 and D5) receptors that stimulate adenylyl cyclase and D2-like (D2, D3 and D4) receptors that inhibit adenylyl cyclase. Both the D1-like and D2-like receptors are expressed in the kidn...

Oncogenic mechanisms in Burkitt lymphoma.

Burkitt lymphoma is a germinal center B-cell-derived cancer that was instrumental in the identification of MYC as an important human oncogene more than three decades ago. Recently, new genomics technologies have uncovered several additional oncogenic mechanisms that cooperate with MYC to create this highly aggressive cancer. The transcription factor TCF-3 is central to Burkitt lymphoma pathogen...

[Acute renal insufficiency].

Familial renal insufficiency.

The picture of chronic renal insufficiency in childhood is not common, and instances of more than one member of a family with this picture are comparatively rare. Mitchell (1930), in an exhaustive review of the literature of chronic interstitial nephritis in childhood, quotes 14 instances in which more than one child in the family was affected. Graham and Hutchinson (1941) have described a fami...

Renal insufficiency and failure.

Renal impairment is a common complication of multiple myeloma. Chronic renal failure is classified according to glomerular filtration rate as estimated by the MDRD (modification of diet in renal disease) formula, while RIFLE (risk, injury, failure, loss and end-stage renal disease) and AKIN (acute renal injury network) criteria may be used for the definition of the severity of acute renal injur...